|本期目录/Table of Contents|

[1]全姬善,于婷,李梅,等.胡椒碱对紫杉醇自乳化给药系统口服生物利用度的影响[J].延边大学学报(自然科学版),2017,(02):131-136.
 QUAN Jishan,YU Ting,LI Mei,et al.Effect of piperine on oral bioavailability of paclitaxel self emulsifying drug delivery system[J].Journal of Yanbian University,2017,(02):131-136.
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胡椒碱对紫杉醇自乳化给药系统口服生物利用度的影响()
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《延边大学学报(自然科学版)》[ISSN:1004-4353/CN:22-1191/N]

卷:
期数:
2017年02期
页码:
131-136
栏目:
基础科学研究
出版日期:
2017-07-20

文章信息/Info

Title:
Effect of piperine on oral bioavailability of paclitaxel self emulsifying drug delivery system
作者:
全姬善1 于婷1 李梅1 杨萍1 孙鹏2*
1.延边大学药学院, 吉林 延吉 133000; 2.延边大学附属医院 药剂科, 吉林 延吉 133000
Author(s):
QUAN Jishan1 YU Ting1 LI Mei1 YANG Ping1 SUN Peng2*
1.College of Pharmacy, Yanbian University, Yanji 133000, China; 2.Department of Pharmacy, Yanbian University Hospital, Yanji 133000, China
关键词:
紫杉醇 胡椒碱 自乳化给药系统 SD大鼠 药物动力学
Keywords:
paclitaxel piperine self emulsifying drug delivery system(SEDDS) SD rat pharmacokinetics
分类号:
R944.9
DOI:
-
文献标志码:
A
摘要:
考察胡椒碱对紫杉醇自乳化给药系统(SEDDS)口服生物利用度的影响.首先采用伪三元相图筛选出紫杉醇SEDDS的最优处方,然后利用高效液相色谱法测定SD大鼠口服给药胡椒碱和紫杉醇SEDDS后的血浆中的药物浓度,并考察紫杉醇SEDDS的药物动力学参数.研究结果表明,将P-糖蛋白抑制剂胡椒碱SEDDS与紫杉醇SEDDS联合应用后能显著提高紫杉醇口服生物利用度(P<0.01).
Abstract:
We investigate the effect of piperine on oral bioavailability of paclitaxel self emulsifying drug delivery system(SEDDS). First, the optimal formulation of the paclitaxel SEDDS was screened by pseudo-ternary phase diagram design and then the serum concentrations of paclitaxel SEDDS were detected in SD rats after oral delivery piperine and paclitaxel SEDDS by HPLC. The plasma concentration of paclitaxel was determined by high performance liquid chromatography(HPLC). The oral bioavailability of paclitaxel after single dose was significantly increased by SEDDS(P<0.01)and co-administration of piperine(P<0.01).

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期: 2017-03-20 基金项目: 延边大学科技发展计划项目(2011第23号)
*通信作者: 孙鹏(1976—),男,副主任药师,研究方向为临床药学.
更新日期/Last Update: 2017-06-20