YI Tao,JIN Yingjin,JIA Jingjie,et al.Study on chemical constituents from rhizome of menispermum dauricum[J].Journal of Yanbian University,2017,43(02):128-130.
北豆根化学成分及其活性研究
- Title:
- Study on chemical constituents from rhizome of menispermum dauricum
- 分类号:
- R284..1
- 文献标志码:
- A
- 摘要:
- 利用超声辅助溶剂提取法,正、反相柱色谱及半制备HPLC等分离纯化手段,从植物北豆根中分离得到2个化合物,并利用核磁共振、质谱、红外光谱等对其进行结构鉴定,结果显示这2个化合物分别为蝙蝠葛啡碱(menisporphine)和蝙蝠葛宁碱(dauriporphine).活性实验结果表明,这2个化合物均具有较好的自由基清除活性,抑制率分别为99.8%和92.4%.本文实验结果可为抗氧化和抗老化药物的开发研究提供实验依据.
- Abstract:
- Two compounds were separated and purified from menispermum dauricum using ultrasonic-assisted solvent extraction technology, normal or reverse phase column chromatography and semi-preparative HPLC etc. Their structures were established by NMR, MS and IR spectroscopy experiments. The two compounds were determined as menisporphine(1)and dauriporphine(2). Compounds 1 and 2 showed remarkable scavenging activity toward DPPH. Inhibition rate are 99.8% and 92.4%, respectively. The results of this paper provide experimental basis for the development of anti-oxidation and anti-aging drugs.
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备注/Memo
收稿日期: 2017-05-24 基金项目: 吉林省科技发展计划项目(20140101044JC)
*通信作者: 李熙峰(1969—),男,教授,研究方向为天然物化学.