[1]曹思明,韩立杰,张玲,等.榛花粉不同提取物组分抗炎症活性研究[J].延边大学学报(自然科学版),2015,41(04):326-330.
　CAO Siming,HAN Lijie,ZHANG Ling,et al.Research of anti-inflammatory activity for difference Hazel pollen extracts[J].Journal of Yanbian University,2015,41(04):326-330.
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榛花粉不同提取物组分抗炎症活性研究

《延边大学学报(自然科学版)》[ISSN:1004-4353/CN:22-1191/N] 卷: 第41卷 期数: 2015年04期 页码: 326-330 栏目: 应用科学研究 出版日期: 2015-12-20
Title:
Research of anti-inflammatory activity for difference Hazel pollen extracts
文章编号:
1004-4353(2015)04-0326-05
作者:
曹思明1;  韩立杰2;  张玲2;  金铁岩1; 2*
1.延边大学理学院 化学系, 吉林 延吉 133002;
2.延边大学农学院 食品科学系, 吉林 延吉 133002
Author(s):
CAO Siming1;  HAN Lijie2;  ZHANG Ling2;  JIN Tieyan1; 2*
1.Department of Chemistry, College of Science, Yanbian University, Yanji 133002, China;
2.Department of Food Science, College of Agriculture, Yanbian University, Yanji 133002, China
关键词:
榛花粉;  乙醇提取物;  抗炎症活性
Keywords:
Hazel pollen;  ethanol extract;  anti-inflammatory activity
分类号:
TS202.1
文献标志码:
A
摘要:
以榛花粉为原材料,得到榛花粉乙醇提取物,然后分别利用不同溶剂对榛花粉乙醇提取物进行提取得到不同组分; 将榛花粉不同提取组分对RAW 264.7细胞进行抗炎症实验、PGE2生成实验、诱发胃炎和肝炎的动物实验,实验结果表明:二氯甲烷组分和乙酸乙酯组分都对RAW 264.7细胞中NO和PGE2的生成具有明显的抑制效果,且均存在较高的浓度依存性关系; 二氯甲烷组分对胃炎病变部位有一定治疗作用,对肝损伤细胞中的ALT活性的升高具有一定抑制作用.
Abstract:
We used Hazel pollen as raw material, obtained Hazel pollen ethanol extract, then using different solvents to extract them to get different components which were checked with RAW 264.7 cells anti-inflammatory, PGE2, induced gastritis and hepatitis animal. The results show that methylene chloride and ethyl acetate extracted components have significant inhibitory effect on generation of NO and PGE2 of RAW 264.7 cells and higher concentration dependence relationship; Methylene chloride extracted component has the rapeutic effect on gastritis lesions and can reduce elevated ALT activity in injured liver cells with a certain extent.

参考文献/References:

[1] 刘新成,孙佳明,白路,等.榛花化学成分研究[J].中国现代医药,2013,15(11):940-942.
[2] 南京中医药大学.中药大辞典:下册[M].上海:上海科技技术出版社,2006:3561.
[3] 蔡英兰,金政,金香子,等.榛花对糖尿病小鼠降糖作用及对肝脏和胰岛病理学影响[J].辽宁中医杂志,2005,32(12):1324-1326
[4] 师伟.榛花中抑制金黄色葡萄球菌化合物的筛选及抑菌机制的研究[D].沈阳:辽宁师范大学,2011:26-47
[5] 高国粉,衰利佳,刘仙,等.榛花总黄酮的提取及抗氧化活性的研究[J].中华中医药杂志,2007,8:547-549.
[6] Limsuwan S, Hesseling-Meinders A, Voravuthikunchai S P, et al. Potential antibiotic and anti-infective effects of rhodomyrtone from Rhodomyrtus to mentosa(Aiton) Hassk.on Streptococcus pyogenes as revealed by proteomics[J]. Phytomedicine, 2011,18(11):934-940.
[7] 黄桂东,钟先锋,吴龙奇,等.共轭亚油酸混合物对人结肠癌细胞(Caco-2)的抑制作用[J].食品与机械,2007,23(4):49-51.
[8] Jeong D, Yang W S, Yang Y, et al. In vitro and in vivo anti-inflammatory effect of Rhodomyrtus tomentosa methanol extract[J]. Journal of Ethnopharmacology, 2013,146(1):205-213.
[9] Yang Y, Yu T, Jang H J, et al. In vitro and in vivo anti-inflammatory activities of Polygonum hydropiper methanol extract[J]. Journal of Ethnopharmacology, 2011,139(2):616-625.
[10] Lee S J, Park J Y, Choi K S, et al. Efficacy of Korean red ginseng supplementation on eradication rate and gastric volatile sulfur compound levels after Helicobacter pylori eradication therapy[J]. Journal of Ginseng Research, 2010,34(2):122-131.
[11] Abu-Ghefreh A A, Canatan H, Ezeamuzie C I. In vitro and in vivo anti-inflammatory effects of andrographolide[J]. International Immunopharmacology, 2009,9(3):313-318.
[12] Cho J Y, Yeon J D, Kim J Y, et al. Hepatoprotection by human epidermal growth factor(hEGF)against experimental hepatitis induced by D-galactosamine(D-galN)or D-GalN/lipopolysaccharide[J]. Biological & Pharmaceutical Bulletin, 2000,23(10):1243-1246.
[13] 刘建文.药理实验方法学:新技术与新方法[M].北京:化学工业出版社,2008.
[14] Palmes D, Spiegel HU. Animal models of liver regeneration[J]. Biomaterials, 2004,25(9):1601-1611.
[15] 齐志宏.天门冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)37 ℃参考测定程序的建立及其临床应用[D].北京:中国协和医科大学,2006.

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备注/Memo

通信作者: 金铁岩(1968—),男,博士,副教授,研究方向为功能性食品.

更新日期/Last Update: 2015-12-20