LUAN Junying,CHI Wanfu,HAN Rongbi*.Synthesisand physiological activity research of betulin pyridinium salt derivatives[J].Journal of Yanbian University,2014,40(02):117-120.
桦木醇吡啶盐衍生物的合成及其生理活性研究
- Title:
- Synthesisand physiological activity research of betulin pyridinium salt derivatives
- Keywords:
- betulin; pyridine salt derivatives; MTT assay; anti-cancer activity
- 分类号:
- O625.25
- 文献标志码:
- A
- 摘要:
- 以桦木醇为原料合成了4种桦木醇吡啶盐,运用1H-NMR和IR确认了化合物的结构.用噻唑蓝(MTT)比色法对这4种化合物对肝星状细胞、人肺癌细胞和人肝癌细胞的抑制作用进行了活性分析,结果表明,化合物3、4a和4c对上述3种癌细胞有明显的抑制作用,并且对肝星状细胞的IC50值均明显低于桦木醇.
- Abstract:
- Four betulin pyridinium salts were prepared from botulin. The structure of the products were identified by 1H-NMR and IR. In order to study the effects of betulin pyridinium salts on inhibiting tumor cells, activity analysis of compounds 3 and 4a-c on the HSC cell, A549 cell and HepG 2 was carried out by MTT assay. The results showed that compounds 3, 4a and 4c had obvious inhibitory action on the HSC cell, A549 cell and HepG 2. On HepG 2 cells, IC50 of compounds 3, 4a and 4c were significantly lower than IC50 of betulin.
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备注/Memo
收稿日期: 2014-03-20 *通信作者: 韩荣弼(1962—),男,教授,研究方向为有机合成化学.基金项目: 国家自然科学基金资助项目(21362039); 吉林省科技发展计划项目(20130101025JC)