CHU Libin,WANG Geyang,PIAO Fengyu,et al.Synthesis, characterization and biological activity of cooper(II), silver(I), palladium(II)and cadmium(II)complexes of betulone thiosemicarbazone[J].Journal of Yanbian University,2016,42(01):29-38.
桦木酮缩氨基硫脲铜、银、钯、镉金属配合物的合成、表征与生物活性研究
- Title:
- Synthesis, characterization and biological activity of cooper(II), silver(I), palladium(II)and cadmium(II)complexes of betulone thiosemicarbazone
- Keywords:
- Betulin; thiosemicarbazone; complex; antimicrobial activity; inhibitory
- 分类号:
- O629.6+1
- 文献标志码:
- A
- 摘要:
- 运用拼合原理,合成了4种桦木酮缩氨基硫脲配体及其铜、银、镉、钯金属配合物,通过核磁共振氢谱(1H NMR)、红外光谱(IR)、元素分析、热重谱(TG)、飞行时间质谱(MALDI-TOF-MS)和元素分析对配体和配合物进行了结构表征.以最小抑菌浓度(MIC)评价了S.aureus 4220、S.mutans 3289、S.mutans 3065、E.coli 1924和E.coli 1356的抑菌活性.结果表明:Ag(L4)2Cl2·2H2O对S.aureus 4220、S.mutans 3065和E.coli 1924具有相对较好的抑制作用; Ag(L1)2NO3·2MeOH、Cu(L3)2Cl2·H2O、Ag(L3)2Cl·3H2O、Cd(L3)2Cl2、Cu(L4)2Cl2和Ag(L4)2Cl2·2H2O对Hela细胞有显著的抑制作用.
- Abstract:
- Four betulone thiosemicarbazone ligands and their copper(II), silver(I), cadmium(II)and palladium(II)metal complexes were prepared by combination principle and characterized by 1H NMR, IR, TG, MALDI-TOF-MS, elemental analysis. Their antimicrobial activities on S.aureus 4220, S.mutans 3289, S.mutans 3065, E.coli 1924 and E.coli 1356 were evaluated by mininum inhibitory concentration(MIC). The results showed that the complex Ag(L4)2Cl2·2H2O has relatively good inhibitory effects on S.aureus 4220, S.mutans 3065 and E.coli 1924. Ag(L1)2NO3·2MeOH, Cu(L3)2Cl2·H2O, Ag(L3)2Cl·3H2O, Cd(L3)2Cl2, Cu(L4)2Cl2 and Ag(L4)2Cl2·2H2O have obvious inhibitory effects on the Hela cell.
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备注/Memo
收稿日期: 2016-02-01 *通信作者: 韩荣弼(1962—),男,教授,研究方向为有机合成化学. 基金项目: 国家自然科学基金资助项目(21362039); 吉林省科技发展计划项目(20130101025JC)