TONG Qingqing,XU Mingyou,JIN Chunmei.The preparation of Dryopteris crassirhizoma Nakai extract effervescent tablets and its preliminary study for the effect of pet deworming[J].Journal of Yanbian University,2023,(03):262-267.
东北贯众提取物泡腾片的制备及其对宠物驱虫效果的初步研究
- Title:
- The preparation of Dryopteris crassirhizoma Nakai extract effervescent tablets and its preliminary study for the effect of pet deworming
- 文章编号:
- 1004-4353(2023)03-0262-06
- Keywords:
- Dryopteris crassirhizoma Nakai extract; effervescent tablet; orthogonal method; effect of deworming; Toxoplasma gondii
- 分类号:
- R944.4
- 文献标志码:
- A
- 摘要:
- 以东北贯众提取物为主药,采用酸碱分开制粒后压片工艺制备了一种具有驱虫效果的东北贯众提取物泡腾片.正交实验显示,该泡腾片的最佳配方(质量分数)为:东北贯众提取物4.0%, 复合维生素0.2%, 柠檬酸29.5%, 碳酸氢钠15.5%, 糖粉15.0%, 滑石粉0.15%, β- 环糊精35.65%.经测定显示,该泡腾片对小鼠腹腔内的弓形虫的抑制率与螺旋霉素相当,且其重量差异、崩解时限、硬度、pH、发泡量均符合2020版 《中华人民共和国药典》 中的相关标准,因此该东北贯众提取物泡腾片可作为一种潜在的宠物驱虫药物进行进一步研究.
- Abstract:
- A pet deworming effervescent tablet was prepared using Dryopteris crassirhizoma Nakai extract as the main ingredient and employing a process of granulation of acid and alkali separation.Orthogonal experiments results showed that the optimal formula(mass fraction)for the effervescent tablet was as follows:4.0% of Dryopteris crassirhizoma Nakai extract, 0.2% of multivitamin, 29.5% of citric acid, 15.5% of sodium bicarbonate, 15.0% of powdered sugar, 0.15% of talcum powder and 35.65% of β - cyclodextrin.The results showed that the Dryopteris crassirhizoma Nakai extract effervescent tablet has a similar inhibitory rate against Toxoplasma gondii in the abdominal cavity of mice as spiramycin, and its weight difference, disintegration time, hardness, pH, and foaming capacity met the standards of the 2020 edition of the Pharmacopoeia of the People’s Republic of China.Therefore, the Dryopteris crassirhizoma Nakai extract effervescent tablet can be further studied as a potential pet deworming medicine.
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备注/Memo
收稿日期: 2023-06-19
基金项目: 吉林省大学生创新创业训练计划(S202210184031)
第一作者: 童青青(2002—),女,本科生,研究方向为天然药物抗感染.
通信作者: 金春梅(1973—),女,博士,教授,研究方向为天然药物抗感染.