LIN Jianhu,LIN Wenxiong.Preparation and optimization of nicotine loaded solid lipid nanoparticles as insecticide[J].Journal of Yanbian University,2022,(01):66-71.
一种烟碱固体脂质纳米粒杀虫剂的制备与优化
- Title:
- Preparation and optimization of nicotine loaded solid lipid nanoparticles as insecticide
- 文章编号:
- 1004-4353(2022)01-0066-06
- Keywords:
- insecticide; high pressure homogenization; nicotine; solid lipid nanoparticles; hydrogenated sunflower oil
- 分类号:
- R944.9
- 文献标志码:
- A
- 摘要:
- 针对传统烟碱类杀虫剂易污染环境的问题,设计开发了一种处方材料、生产过程都相对环保的烟碱固体脂质纳米粒杀虫剂.实验结果表明:烟碱固体脂质纳米粒的最优处方为8.5%的氢化葵花籽油(脂质)、2.0%的聚乙烯醇61000(稳定剂)、1.5%的烟碱(主药)和加至100.0%的Na2CO3-NaHCO3缓冲液(介质,pH 9.0).制备烟碱固体脂质纳米粒的最佳工艺为在600 bar下高压匀质法循环7次.在最优处方和最佳工艺下,制备得到的固体脂质纳米粒的
- Abstract:
- The traditional neonicotinoid insecticide could broke ecological balance, thus we designed nicotine loaded solid lipid nanoparticles(N - SLN)which contain environmental friendly ingredients and producing process. The results showed that the optimized formulation is 8.5% hydrogenated sunflower oil(HSO)as lipid phase, 2.0% PVA 61000 as stabilizer, 1.5% nicotine as active agent and up to 100.0% Na2CO3-NaHCO3 buffer(pH 9.0)as medium. The optimized preparation process of N - SLN is using high pressure homogenization at 600 bar for 7 cycles. Under the optimized formulation and preparation process, the size characteristics of the produced N - SLN did not make a significant change within 30 days as following: the photon correlation spectroscopy(PCS)mean size was 452 nm, the diameter analyzed by laser diffractometer was that more than 50% particles were smaller than 342 nm, more than 99% particles were smaller than 850 nm, and the poly-dispersity index(PDI)was 0.277. The encapsulation efficiency of nicotine was(12.3±4.2)%. The N - SLN fabricated in this study paves the way for more environmental friendly insecticide.
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备注/Memo
收稿日期: 2021-10-15
基金项目: 福建农林大学校科技创新专项基金(CXZX2017308); 闽台作物特色种质创制与绿色栽培协同创新中心项目[闽教科(2015)75号]; 福建省教育科学“十四五”规划项目(FJJKBK21-077)
第一作者: 林建胡(1984—),男,硕士,助理研究员,研究方向为资源与环境生态学.
通信作者: 林文雄(1957—),男,博士,教授,研究方向为作物生理与分子生态学.