YOU Yue,XU Lingshan,GUO Jianpeng*.Preparation process and anti-rheumatoid arthritis investigation of XUN HUAN TONG LUO ointments[J].Journal of Yanbian University,2018,44(03):250-255.
“循环通络”乳膏剂制备及其抗类风湿性关节炎的考察
- Title:
- Preparation process and anti-rheumatoid arthritis investigation of XUN HUAN TONG LUO ointments
- 分类号:
- R944.9
- 文献标志码:
- A
- 摘要:
- 以综合评分为指标,通过正交设计试验优选“循环通络”乳膏剂处方,并采用单因素试验对其制备工艺参数进行了优化.研究表明,乳膏剂的最佳处方为浓缩药液200 g、凡士林90 g、羊毛脂10 g、液体石蜡80 g、单硬脂酸甘油酯50 g、硬脂酸65 g、丙三醇150 g、吐温80 40 g、月桂氮艹/卓酮10 g、尼泊金乙酯0.5 g,用水加至1 000 g.制备的最佳工艺为油、水相分别加入乳化,搅拌速度为250 r·min-1,乳化温度为70 ℃,乳化时间为15 min.抗类风湿性关节炎实验
- Abstract:
- Based on the comprehensive score as the index, the orthogonal design experiment was used to select the prescription of XUN HUAN TONG LUO ointments, and the single factor experimental method was used to optimize the process parameters. The optimum prescription of ointments is finally obtained as a concentrated liquid 200 g, petrolatum 90 g, lanolin 10 g, liquid paraffin 80 g, glyceryl monostearate 50 g, stearic acid 65 g, glycerol 150 g, Tween-80 40 g, laurocapram 10 g, ethylparaben 0.5 g, and add water to 1 000 g. The optimum process implied that emulsification is attributed to add two phases of oil and water respectively, the stirring speed of 250 r·min-1, the emulsification temperature of 70 ℃ and the emulsification time of 15 min. Anti-rheumatoid arthritis experiments showed that the ointments can improve joint swelling in rats, reduce the levels of inflammatory factors(TNF-α, IL-1β and IL-6)in the serum of rats, increase the content of anti-inflammatory factor(IL-10).
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备注/Memo
收稿日期: 2018-06-23 基金项目: 延边朝鲜族自治州科技发展计划项目(2014AC17)
*通信作者: 郭建鹏(1971—),男,教授,研究方向为中药新剂型与新技术.