DING Xiao,GUO Xuejian,DONG Yanchen,et al.Elucidation for chemical constituents of Rhodiola sachalinensis A.Bor.[J].Journal of Yanbian University,2018,44(02):129-133，188.
库页红景天化学成分的鉴定
- Title:
- Elucidation for chemical constituents of Rhodiola sachalinensis A.Bor.
- 分类号:
- R284.1
- 文献标志码:
- A
- 摘要:
- 采用70%乙醇(体积百分比)回流提取,结合硅胶、Sephadex LH-20、大孔吸附树脂及半制备高效液相等分离纯化方法,在库页红景天的根茎中分离得到20个化合物.利用核磁共振谱、质谱结构鉴定出所得20个化合物分别为十一烷(1)、三十五烷(2)、邻苯二甲酸二丁酯(3)、没食子酸甲酯(4)、2,6-二甲氧基-4-羟基苯乙酮(5)、2,4-二羟基-6-甲氧基苯乙酮(6)、对羟基苯甲酸(7)、2(R)-26-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]oxy]-2,3-dihydroxypropyl ester(8)、咖啡酸(9)、没食子酸(10)、酪醇(11)、山柰酚(12)、4,6-二羟基-2-O-(β -D-吡喃葡萄糖苷)-苯乙酮(13)、2,6-二甲氧基-4-O-(β -D-吡喃葡萄糖苷)-苯乙酮(14)、熊果苷(15)、苏丹三(16)、大黄素(17)、芦丁(18)、木犀草苷(19)、3’-甲氧基木犀草素-7-O- β -D葡萄糖苷(20),其中(1)、(2)、(4)、(5)、(6)、(8)、(13)、(14)、(16)、(17)、(19)、(20)为首次从库页红景天中分离得到,(2)、(5)、(8)、(13)、(16)、(17)、(20)为首次从红景天属植物中分离得到.
- Abstract:
- Twenty compounds are isolated from the rhizomes of Rhodiola sachalinensis A.Bor.by extracting with 70% ethanol(volume percentage)under reflux, combined with silica gel, Sephadex LH-20, macroreticular resin column chromatography and semi-preparative HPLC. The chemical structures of isolated compounds are elucidated by NMR and MASS.They are identified to be undecane(1), pentatriacontane(2), dibutyl phthalate(3), methyl gallate(4), 2,6-dimethoxy-4-hydroxyacetophenone(5), 2,4-dihydroxy-6-methoxyphenylethanone(6), p-hydroxybenzoic acid(7), 2(R)-26-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]oxy]-2,3-dihydroxypropyl ester(8), caffeic acid(9), gallic acid(10), tyrosol(11), kaempferol(12), 4,6-dihydroxy-2-O-(β -D-glucopyranosyl)acetophenone(13), 2,6-dimethoxy acetopheonone-4-O-(β -D-glucopyranosyl)acetophenone(14), arbutin(15), sudan III(16), emodin(17), rutin(18), galuteolin(19), and 3’-methoxyl luteolin-7-O- β -D-glucoside(20). Among them,(1),(2),(4),(5),(6),(8),(13),(14),(16),(17),(19)and(20)are isolated from Rhodiola sachalinensis A.Bor.for the first time,(5),(8),(13),(16),(17)and(20)are firstly obtained from the genus Rhodiola.
参考文献/References:
[1] Nakamura S, Li X, Matsuda H, et al. Bioactive constituents from Chinese natural medicines.XXVI.Chemical structures and hepatoprotective effects of constituents from roots of Rhodiola sachalinensis[J]. Chemical & Pharmaceutical Bulletin, 2007,55(10):1505-1511.
[2] 王爱玲,曲玮,梁敬钰.红景天属植物化学成分及药理作用研究进展[J].海峡药学,2014,26(1):1-8.
[3] 杨文婷,张伟,杨一丁,等.红景天化学成分研究[J].首都食品与医药,2015,22(22):90-91.
[4] Choe K I, Kwon J H, Park K H, et al. The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A.BOR.[J]. Molecules, 2012,17(10):11484-11494.
[5] Song E K, Kim J H, Kim J S, et al. Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells[J]. Phytotherapy Research, 2003,17(5):563-565.
[6] 倪付勇.高山红景天抗补体活性成分研究[D].苏州:苏州大学,2013:4-5.
[7] 王宁.岭南山竹子叶化学成分研究[D].海口:海南大学,2012:38.
[8] 褚纯隽,李显伦,夏龙,等.乌饭树叶的抗补体活性成分研究[J].中草药,2014,45(4):458-465.
[9] Lu Xinhua, Zhang Jinjuan, Liang Hong, et al. Chemical constituents of Angelica Sinensis[J]. Journal of Chinese Pharmaceutical Sciences, 2004,13(1):1-3.
[10] 任源.没食子化学成分及溃结安灌肠剂的研究[D].乌鲁木齐:新疆医科大学,2005:10.
[11] Azizuddin, Choudhary M I. Compounds isolated from Tannacetum polycephalum[J]. Turkish Journal of Chemistry, 2008,32(2):201-204.
[12] 昝珂,过立农,郑健,等.民族药材青阳参的化学成分研究[J].中国中药杂志,2016,41(1):101-105.
[13] Yu J Q, Xian Y X, Geng Y L, et al. Anti-liver cancer constituents from the thorns of Gleditsia sinensis[J]. Phytochemistry Letters, 2015,13(4):343-347.
[14] 金朝娜.浙江蜂胶的化学成分研究[D].大连:大连理工大学,2008:52-53.
[15] 何江波,刘光明,程永现.蜂房化学成分研究[J].中草药,2011,42(10):1905-1908.
[16] 周先礼,吴奶珠,黄帅,等.藏药樱草杜鹃中的酚类成分[J].中国药学杂志,2012,47(2):95-97.
[17] Zong Y, Lowell K, Ping J A, et al. Phenolic constituents of Rhodiola coccinea, a Tibetan folk medicine[J]. Planta Medica, 1991,57(6):589.
[18] 罗旭璐.樟叶越桔原植物及其组织培养系的化学成分分析[D].昆明:西南林业大学,2015:38-39.
[19] Lycka A, Hansen P E. Deuterium isotope effects on 13C and 15N nuclear shielding in o -hydroxyazo dyes[J]. Magnetic Resonance in Chemistry, 1984,22(9):101-115.
[20] 李明月,常敏,张庆华,等.木榄内生真菌菌株ZD6及其代谢产物的抑菌活性[J].菌物学报,2010,29(5):739-745.
[21] 张倩.天山花楸枝叶化学成分的研究[D].乌鲁木齐:新疆医科大学,2012:23-26.
[22] 毛媛.东紫苏中木犀草苷的分离及其生物活性研究[D].上海:上海海洋大学,2016:22-24.
[23] 杨爱梅,鲁润华,师彦平.藏药圆穗兔耳草中的黄酮类化合物[J].中国药学杂志,2007,42(19):1459-1461.
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备注/Memo
*通信作者: 许光华(1968—),男,副教授,研究方向为天然活性成分.
基金项目: 吉林省卫生技术创新项目(012016057); 延边大学科技发展应用项目(602015005)