GUAN Qixuan,WU Jing,WANG Helin,et al.Effect of effective components of “Qianjin Wenwu Tang” ondiabetic kidney disease models[J].Journal of Yanbian University,2017,43(03):230-232，276.
朝医方“千金文武汤”有效组分对糖尿病肾病模型的影响
- Title:
- Effect of effective components of “Qianjin Wenwu Tang” on diabetic kidney disease models
- Keywords:
- Chaoyao compound; diabetic kidney disease; oxidative stress
- 分类号:
- R965.1
- 文献标志码:
- A
- 摘要:
- 为考察朝医方“千金文武汤”特定配比的有效组分对糖尿病肾病模型的影响,采用链脲佐菌素结合高脂饲料建立小鼠糖尿病肾病模型,并给予低、中、高剂量的受试品; 连续给药8周后,以空腹血糖值、肾重指数、超氧化物歧化酶(SOD)、丙二醛(MDA)以及肿瘤坏死因子α(TNF-α)为指标对小鼠肾脏进行检测.结果显示:与对照组相比,受试品能显著降低小鼠空腹血糖值,改善肾重指数,增加肾脏组织SOD的活性,降低肾脏组织MDA的含量.这表明“千金文武汤”有效组分对糖尿病肾病小鼠的肾脏损害有一定的保护作用,该机理可能与其增强组织的抗
- Abstract:
- The specific ratio of effective component which effects on the diabetic and kidney disease(DKD)animal models for a kind of Korean medical prescription named "Qianjin Wenwu Tang" is evaluated. The DKD models was established by means of streptozotocin combined with high fat diet, furthermore, the low, medium and high dose of gavage were for 8 weeks. The levels of blood glucose, renal weight index, superoxide dismutase(SOD), malondialdehyde(MDA)and tumor necrosis factor α(TNF-α)were used target to observe the kidney. abnormalities and oxidative damage. Compared with the control group, the test substance could significantly decrease the blood glucose level, improve the renal weight index, increase the activity of SOD in kidney tissue and decrease the content of MDA. The effective components of "Qianjin Wenwu Tang" imply protective effect on the kidney damage of mice for DKD models, thus, the mechanism may be related with enhance the antioxidant capacity and regulate the level of inflammatory factors in the body.
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备注/Memo
收稿日期: 2017-07-23 *通信作者: 郭建鹏(1971—),男,教授,研究方向为新剂型与新技术.
基金项目: 国家自然科学基金资助项目(81660709); 吉林省科技发展计划项目(20140204034YY)