AO Yutao,GUAN Qixuan,DING Xue,et al.The extraction technology of the total polyphenol of Rhodiola sachalinensis and its the preparation of the dispersible tablets[J].Journal of Yanbian University,2016,42(02):173-176.
长白山生物资源开发研究与利用高山红景天总多酚提取工艺及其分散片制备
- Title:
- The extraction technology of the total polyphenol of Rhodiola sachalinensis and its the preparation of the dispersible tablets
- Keywords:
- Rhodiola sachalinensis; ultrasonic and circulated extraction; the multi-index comprehensive score; auxiliary hypoglycemic function
- 分类号:
- R944.4
- 文献标志码:
- A
- 摘要:
- 采用超声循环法提取高山红景天中多酚类成分,以总多酚提取率为指标,考察提取溶剂、料液比和超声参数对提取率的影响,并对提取工艺进行优选,得出最佳工艺为:40%乙醇为提取溶剂,料液比为1:12,间隔超声时间比为0.6:0.5,提取时间为1 h,超声功率为500 W.在最佳工艺条件下,总多酚提取率为(28.71±0.75)mg·g-1.以提取物为原料,分别选用MCC、L-HPC和PVP乙醇溶液为分散片的填充剂、崩解剂和黏合剂制备高山红景天总多酚分散片,经检测各项指标符合药典规定.所制备的分散片具有辅助降血糖保健功能.
- Abstract:
- To extract polyphenols from Rhodiola sachalinensis by ultrasonic and circulated method, the effect of extraction solvent, the ratio of material to solvent, ultrasound parameter were analyzed with amount of total polyphenol, and these technology were optimized. The ratio of material to liquid was 1:12 by using 40% ethanol as extraction solvent, the ratio of the time of interval of ultrasonic was 0.6:0.5, extracting time was 1 h and the ultrasonic power was 500 W for the best extraction process, the extraction rate of total polyphenol was(28.71±0.75)mg·g-1. Total polyphenol of Rhodiola sachalinensis dispersible tablets were prepared with screening pharmaceutical formulations, the MCC, L-HPC and 2% PVP were selected as filler, disintegrant and binder. Dispersible tablets were in accordance with regulation and have the auxiliary hypoglycemic effects on health care.
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相似文献/References:
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DING Xue,LIU He,AO Yutao,et al.Determination of the content of salidroside and pesticide residues of Rhodiola Sachalinensis in Changbai Mountains[J].Journal of Yanbian University,2014,40(02):273.
备注/Memo
收稿日期: 2016-04-26 基金项目: 吉林省科技发展计划项目(20130727071YY,20140204034YY)*通信作者: 郭建鹏(1971—),男,教授,研究方向为中药新剂型与新技术.